Self‐Assembled Nanoreactors as Highly Active Catalysts in the Hydrolytic Kinetic Resolution (HKR) of Epoxides in Water

Abstract

CoIII(salen) complexes have been immobilized on amphiphilic block copolymers, which self-assemble in water to give micellar aggregates with a hydrophobic Co(salen) core and a water-soluble shell (see picture). These aggregates were used to catalyze the hydrolytic kinetic resolution (HKR) of racemic aromatic epoxides over four consecutive cycles and gave the epoxides in up to 99 % ee. H2salen=N,N′-bis(salicylidene)ethylenediamine. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z503291_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.