Enrichment of Low‐Abundance Peptides and Proteins on Zeolite Nanocrystals for Direct MALDI‐TOF MS Analysis

Abstract

Concentrated efforts: A zeolite-nanocrystal-mediated enrichment procedure that doubles as a desalting step allows low-abundance proteins to be readily detected with MALDI-TOF MS (see picture). Mass spectral signal-to-noise ratios are greatly improved for a wide range of peptides, which underscores the potential of this procedure to boost proteomics research.