Concepedia

Androgen receptor‐dependent regulation of Bcl‐xL expression: Implication in prostate cancer progression

Aijing Sun, Jianxi Tang, Yan Hong, Jiawu Song, Paul F. Terranova, J. Brantley Thrasher, Stan R. Svojanovsky, Hong‐Gang Wang, Benyi Li

The Prostate · 2008 · 36 citations · 32 references

DOI

Abstract

Taken together, our data strongly suggest that androgen stimulates Bcl-xL expression via the AR and that increased Bcl-xL expression plays a versatile role in castration-resistant progression of prostate cancer.

References

32

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

Lawrence Boise, Maribel González‐García, C E Postema et al. · Cell · 1993 · 3.1K citations · Full text

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A Hierarchical Network of Transcription Factors Governs Androgen Receptor-Dependent Prostate Cancer Growth

Qianben Wang, Wei Li, X. Shirley Liu et al. · Molecular Cell · 2007 · 700 citations · Full text

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Mouse Development and Cell Proliferation in the Absence of D-Cyclins

Katarzyna Kozar, Maria A. Ciemerych, Vivienne I. Rebel et al. · Cell · 2004 · 645 citations · Full text

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Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers.

M Krajewska, S Krajewski, JI Epstein et al. · PubMed · 1996 · 596 citations

Gene Expression Analysis of Human Prostate Carcinoma during Hormonal Therapy Identifies Androgen-Responsive Genes and Mechanisms of Therapy Resistance

Jeff M. Holzbeierlein, Priti Lal, Éva Latulippe et al. · American Journal Of Pathology · 2004 · 571 citations

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