Developmental Changes in P-Glycoprotein Function in the Blood–Brain Barrier of Nonhuman Primates: PET Study with<i>R</i>-<sup>11</sup>C-Verapamil and<sup>11</sup>C-Oseltamivir - Concepedia

Concepedia

Publication | Open Access

Developmental Changes in P-Glycoprotein Function in the Blood–Brain Barrier of Nonhuman Primates: PET Study with<i>R</i>-<sup>11</sup>C-Verapamil and<sup>11</sup>C-Oseltamivir

DOI Full Paper Access

50

Citations

32

References

2011

Year

Tadayuki Takashima, Chihiro Yokoyama, Hiroshi Mizuma, Hajime Yamanaka, Yasuhiro Wada, Kayo Onoe, Hiroko Nagata, Shusaku Tazawa, Hisashi Doi, Kazuhiro Takahashi,

Journal of Nuclear Medicine

Abstract

These results suggest that P-gp function in the BBB changes with development in rhesus monkeys, and this change may be closely related to the observed difference in drug responses in the brains of children and adult humans.

References

	Year	Citations

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