Synthesis of functionalized isoxazole–oxindole hybrids <i>via</i> on water, catalyst free vinylogous Henry and 1,6-Michael addition reactions

Abstract

Various isoxazole–oxindole hybrids were synthesized <italic>via</italic> vinylogous Henry reaction of 3,5-dimethyl-4-nitroisoxazole and isatin under catalyst free conditions in water. The products obtained were functionalized using 1,6-Michael addition reaction.