Acromegaly: An Endocrine Society Clinical Practice Guideline

TLDR

The guideline was developed to provide evidence-based recommendations for the evaluation and management of acromegaly. The guideline was produced by a multidisciplinary Task Force that reviewed primary evidence, commissioned systematic reviews, and used the GRADE system to rate recommendations, with consensus achieved through meetings and communications. The guideline recommends a comprehensive biochemical assessment, a therapeutic algorithm incorporating medical monotherapy or combination therapy, and specific guidance for management during pregnancy. The authors received no corporate funding or remuneration.

Abstract

The aim was to formulate clinical practice guidelines for acromegaly.The Task Force included a chair selected by the Endocrine Society Clinical Guidelines Subcommittee (CGS), five experts in the field, and a methodologist. The authors received no corporate funding or remuneration. This guideline is cosponsored by the European Society of Endocrinology.This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe both the strength of recommendations and the quality of evidence. The Task Force reviewed primary evidence and commissioned two additional systematic reviews.One group meeting, several conference calls, and e-mail communications enabled consensus. Committees and members of the Endocrine Society and the European Society of Endocrinology reviewed drafts of the guidelines.Using an evidence-based approach, this acromegaly guideline addresses important clinical issues regarding the evaluation and management of acromegaly, including the appropriate biochemical assessment, a therapeutic algorithm, including use of medical monotherapy or combination therapy, and management during pregnancy.