Chronic Methadone Treatment Shows a Better Cost/Benefit Ratio than Chronic Morphine in Mice

Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.

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Morphine Activates Opioid Receptors without Causing Their Rapid Internalization

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Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice.

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Morphine-activated opioid receptors elude desensitization by β-arrestin

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Regulation of Opioid Receptor Trafficking and Morphine Tolerance by Receptor Oligomerization

He Li, Jamie Fong, Mark von Zastrow et al. · Cell · 2002 · 337 citations · Full text

Molecular Pharmacology, Morphine Tolerance, Signal Transduction +11