Identification of novel tylosin analogues generated by a wblA disruption mutant of Streptomyces ansochromogenes

Abstract

Two novel tylosin analogues (compound 1 and 2) were generated by ΔwblA. Bioassays showed that compound 1 and 2 displayed much higher activity than tylosin against Streptococcus pneumoniae, implying that these two compounds might be used to widen the application of tylosin.