Publication | Closed Access
A Short, Efficient, and Stereoselective Total Synthesis of a Pyrrolidine Alkaloid: (−)-Codonopsinine
52
Citations
6
References
2007
Year
Medicinal ChemistryOverall YieldBioorganic ChemistryBiochemistryChiral TemplateStereoselective Total SynthesisNatural SciencesPyrrolidine AlkaloidEfficient Total SynthesisOrganic ChemistryStereoselective SynthesisChemistryPharmacologyAsymmetric CatalysisSynthetic ChemistryEnantioselective SynthesisNatural Product Synthesis
An efficient total synthesis of antibiotic (-)-codonopsinine 1 with an overall yield of 44% was achieved from d-alanine as a chiral template. The key steps in our strategy are modified Sharpless asymmetric dihydroxylation reaction and the highly stereoselective intramolecular acid-catalyzed amidocyclization.
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