Chemical Communications · 2014 · 46 citations · 40 references
Environment-sensitive Coumarin FluorophoreEngineeringFluorescent ImagingNovel Imaging MethodBiotinylated ProbesRational DesignBiomedical ImagingFluorescence ImagingBioimagingCancer CellsFluorescent Probes Sps1Chemical ProbeMedicineCell BiologySingle-molecule DetectionBiophysicsBiomolecular Engineering
Two fluorescent probes SPS1 and SPS2 were designed by connecting biotin to an environment-sensitive coumarin fluorophore. Streptavidin and avidin induced dramatical fluorescence changes in both probes. SPS2 has potential in fluorescent imaging of biotin receptor-enriched tumor cells.
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