Differential modulation of AP‐1‐ and CRE‐driven transcription by cannabinoid agonists emphasizes functional selectivity at the CB₁receptor

Abstract

Together, our results demonstrate that two cannabinoid ligands, commonly used as reference agonists acting on the same receptor with similar affinities, differentially modulate gene transcription through distinct controls of AP-1. This could reflect activation of distinct subsets of Gi/o-proteins, supporting the concept of functional selectivity at CB1 receptors.