Experimental Biology and Medicine · 1953 · 30 citations · 0 references
MedicineRadiation OncologyVeterinary PathologyImmunotoxicologyRadiation BiophysicsRadiobiologyBiological Effects Of RadiationRadiation BiologyRadiation TherapyRadiation ToxicityTissue Responses To RadiationTotal Body IrradiationCellular Radiation DamageCytokine Production By Mast CellsRadiation Dose EffectsRadiation PathogenesisRadiation Syndrome PathophysiologyRadiobiological ResponseTissue Radiation InjuryTissue Reactions
1. The effect of total-body X-irradiation upon the state of the tissue mast cells in the cheek pouch and/or mesentery in the hamster and the mouse was studied. 2. Following exposure there occurred in the tissue mast cells a series of striking changes the end result of which appeared to be disruption of the cell with dispersion of its contents into the surrounding tissues. 3. The possible relationships of these findings to the hemorrhage and clotting defect of the radiation syndrome were discussed.