The central nervous system effects of the partial <scp>GABA</scp>‐<scp>A</scp>α_2,3‐selective receptor modulator <scp>AZD7325</scp> in comparison with lorazepam in healthy males

Abstract

The characteristic ΔSPV-relative effect profiles of AZD7325 vs. lorazepam suggest anxio-selectivity related to α2,3 -selective GABAA agonism. However, exploration of higher doses may be warranted. The paucity of effects on most CNS-PD parameters also indicates a mitigated side effect pattern, with potentially lower cognitive and neurophysiological side effect burden than non-selective benzodiazepines.