<i>APOE</i> ε4 worsens hippocampal CA1 apical neuropil atrophy and episodic memory

Abstract

The APOE ε4 allele segregated dose-dependently and selectively with CA1-SRLM thinning and worse episodic memory performance in a pool of older subjects across a cognitive spectrum. These findings highlight a possible role for this gene in influencing a critical hippocampal subregion and an associated symptomatic manifestation.