Do cardiovascular risk factors explain the link between white matter hyperintensities and brain volumes in old age? A population‐based study

Abstract

The association of global WMHs with lower GM volume and higher ventricular volume is independent of age, VRFs and APOE-ε4 allele, suggesting that the process of cerebral microvascular disease and neurodegeneration are associated independently of the normal aging process, vascular mechanisms or genetic susceptibility.