Paclitaxel loaded human serum albumin nanoparticles stabilized with intermolecular disulfide bonds

Abstract

A self-cross-link strategy was adopted to form inter-protein disulfide crosslinks with albumin's own thiol groups. PTX was further entrapped non-covalently in the HSA matrix to form paclitaxel loaded HSA nanoparticles (PTX-HSA-NPs).