A “Force Buffer” Protecting Immunoglobulin Titin

Abstract

The adventures of titin: in vertebrates, titin filaments control the extendibility of the muscle sarcomere. The titin immunoglobulin 27 unfolds through an intermediate (see structure; arrow: hydrogen bonds ruptured to reach intermediate) that it is highly independent of the force load applied. It is shown that this intermediate acts as a “force buffer” that protects immunoglobulin from unfolding at physiologically applied forces. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.