Enantio‐ and Diastereoselective Ir‐Catalyzed Allylic Substitutions for Asymmetric Synthesis of Amino Acid Derivatives

Abstract

Simply switching the base employed in the first enantioselective allylic substitutions of diphenylimino glycinate 1 with 2, which are catalyzed by an Ir complex of chiral phosphite 5, allows the two branched diastereomers 3 and 4 to be selectively synthesized with little or no formation of linear substitution products.