Catechol O-Methyltransferase Gene Variant and Birth Weight Predict Early-Onset Antisocial Behavior in Children With Attention-Deficit/Hyperactivity Disorder

Abstract

Early-onset antisocial behavior in a high-risk clinical group is predicted by a specific COMT gene variant previously linked with prefrontal cortical function and birth weight, and those possessing the val/val genotype are more susceptible to the adverse effects of prenatal risk as indexed by lower birth weight.