ROS‐Inducible DNA Cross‐Linking Agent as a New Anticancer Prodrug Building Block

Abstract

Down at the crossed code: Novel arylboronic ester and biarylboronic ester derivatives were synthesized. Compound 1 can be activated by hydrogen peroxide to release 2,5-bis(trimethylammonium) benzyl-1,4-diol (2), which leads to interstrand cross-link formation and DNA alkylation (see scheme). Compound 1 provides a novel building block for the development of H2O2-targeting anticancer prodrugs. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.