Evidence for Astrocytosis in Prodromal Alzheimer Disease Provided by ¹¹ C-Deuterium-L-Deprenyl: A Multitracer PET Paradigm Combining ¹¹ C-Pittsburgh Compound B and ¹⁸ F-FDG

Abstract

Increased (11)C-DED binding throughout the brain of the MCI (11)C-PIB+ patients potentially suggests that astrocytosis is an early phenomenon in AD development.