Iron(III) Chloride as Mild and Efficient Reagent for the α-Thiocyanation of Ketones: An Expedient Synthesis of α-Oxo Thiocyanates

Abstract

A simple and efficient method for the α-thiocyanation of ketones has been developed; anhydrous iron(III) chloride is used under mild conditions to produce α-oxo thiocyanates in good to high yields and with high selectivity. The use of inexpensive and readily available iron(III) chloride makes this procedure simple, convenient, and practical.