Comparison of diffuse optical tomography of human breast with whole-body and breast-only positron emission tomography

Soren D. Konecky, Regine Choe, Alper Corlu, Kijoon Lee, Rony I. Wiener, Shyam Srinivas, J.R. Saffer, R. Freifelder, Joel S. Karp, Nassim Hajjioui,

Medical Physics · 2008 · 35 citations · 49 references

DOIFull text

Open access

Concepts

Abstract

We acquire and compare three-dimensional tomographic breast images of three females with suspicious masses using diffuse optical tomography (DOT) and positron emission tomography (PET). Co-registration of DOT and PET images was facilitated by a mutual information maximization algorithm. We also compared DOT and whole-body PET images of 14 patients with breast abnormalities. Positive correlations were found between total hemoglobin concentration and tissue scattering measured by DOT, and fluorodeoxyglucose (18F-FDG) uptake. In light of these observations, we suggest potential benefits of combining both PET and DOT for characterization of breast lesions.

References

49