Cogent Chemistry · 2015 · 15 citations · 33 references
PharmacyMedicinal ChemistryPolymer ChemistrySynthetic Medicinal ChemistrySafer Chemical SynthesisBenzimidazole ChemistryBenzimidazole SynthesisBenzothiazole SynthesisOne-pot Library Synthesis
Polyethylene glycol (PEG-400) was found to be an inexpensive, non-toxic, and effective medium for the one-pot synthesis of 1,2-disubstituted benzimidazoles in excellent yields. Eco-friendliness, low cost, high yields, and recyclability of the PEG-400 are the important features of this protocol.
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Thomas Roth, Marshall Morningstar, Paul L. Boyer et al. · Journal of Medicinal Chemistry · 1997 · 370 citations · Full text
Anthony R. Porcari, Rodrigo V. Devivar, Louis S. Kucera et al. · Journal of Medicinal Chemistry · 1998 · 272 citations · Full text