Functional modulation of the transient outward current Ito by KCNE β-subunits and regional distribution in human non-failing and failing hearts

Abstract

All KCNEs are expressed in the human heart at the transcript level. Compared to I(to) in native human myocytes, none of the combination of KChIP2 and KCNE produced an ideal congruency in current characteristics, suggesting that additional factors contribute to the regulation of the native I(to) channel.