Concepedia

Using aptamers evolved from cell-SELEX to engineer a molecular delivery platform

Prabodhika Mallikaratchy, Haipeng Liu, Yu Fen Huang, Hui Wang, Dalia López‐Colón, Weihong Tan

Chemical Communications · 2009 · 16 citations · 13 references

DOI

Concepts

Abstract

We report a chemically modified construct of the Sgc8 aptamer, selected against CEM cells, conjugated to an activator platform for stimulated release of molecules at the tumor surface using DNA template assisted functional group transfer reactions (DTGTR).

References

13

Aptamers evolved from live cells as effective molecular probes for cancer study

Dihua Shangguan, Ying Li, Zhiwen Tang et al. · Proceedings of the National Academy of Sciences · 2006 · 1.5K citations · Full text

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An Aptamer–Doxorubicin Physical Conjugate as a Novel Targeted Drug‐Delivery Platform

Vaishali Bagalkot, Omid C. Farokhzad, Róbert Langer et al. · Angewandte Chemie International Edition · 2006 · 612 citations

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Selection of Aptamers for Molecular Recognition and Characterization of Cancer Cells

Zhiwen Tang, Dihua Shangguan, Kemin Wang et al. · Analytical Chemistry · 2007 · 481 citations

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Cell-Specific Aptamer Probes for Membrane Protein Elucidation in Cancer Cells

Dihua Shangguan, Zehui Cao, Ling Meng et al. · Journal of Proteome Research · 2008 · 462 citations · Full text

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Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery

Ahn Na Koo, Hong Jae Lee, Sung Eun Kim et al. · Chemical Communications · 2008 · 392 citations

, , +17