Quantitative PET of Human Urokinase-Type Plasminogen Activator Receptor with ⁶⁴Cu-DOTA-AE105: Implications for Visualizing Cancer Invasion

Abstract

Our results clearly demonstrate that the peptide-based PET tracer (64)Cu-DOTA-AE105 enables the noninvasive quantification of uPAR expression in tumors in vivo, thus emphasizing its potential use in a clinical setting to detect invasive cancer foci and for individualized cancer therapy.