Proceedings of the National Academy of Sciences · 1990 · 62 citations · 31 references
Life SciencesNeurobiologyNeuroscienceDevelopmental NeurobiologyDevelopmental NeuroscienceMolecular NeuroscienceDevelopmental NeurophysiologyNeural Circuit FormationNeural DevelopmentNeurotransmissionNeurotransmitter ReceptorsSynaptic TransmissionCortical Circuit DevelopmentEarly Cortical Plate FormationN-methyl-d-aspartate Receptor AntagonismN-methyl-d-aspartate Receptor InhibitionNmda Receptor AntagonismNmda Receptor AntagonistsNmda Receptor FunctionNmda Receptors
Before synapses form in embryonic turtle cerebral cortex, an endogenous neurotransmitter activates N-methyl-D-aspartate (NMDA) channels on neurons in the cortical plate. Throughout cortical development, these channels exhibit voltage-dependent Mg2+ blockade and are antagonized by D-2-amino-5-phosphonovaleric acid, a selective NMDA receptor antagonist. The activation in situ of these nonsynaptic NMDA channels demonstrates a potential physiological substrate for control of early neuronal differentiation.
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Magnesium gates glutamate-activated channels in mouse central neurones
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Molecular distinction between fetal and adult forms of muscle acetylcholine receptor
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