Concepedia

Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure

Guido Iaccarino, Emanuele Barbato, Ersilia Cipolletta, Vincenzo De Amicis, Kenneth B. Margulies, Dario Leosco, Bruno Trimarco, Walter J. Koch

European Heart Journal · 2005 · 190 citations · 35 references

DOI

Abstract

Myocardial GRK2 expression and activity are mirrored by lymphocyte levels of this kinase, and its elevation in HF is associated with the loss of beta-AR responsiveness and appears to increase with disease severity. Therefore, lymphocytes may provide a surrogate for monitoring cardiac GRK2 in human HF.

References

35

Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity.

Gregory J. Hasking, Murray Esler, Garry Jennings et al. · Circulation · 1986 · 1K citations · Full text

, , +14

Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.

Martin Ungerer, Michael Böhm, John S. Elce et al. · Circulation · 1993 · 875 citations · Full text

Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor

Walter J. Koch, Howard A. Rockman, Philippe Samama et al. · Science · 1995 · 714 citations

, , +19

Synergistic Polymorphisms of β<sub>1</sub>- and α<sub>2C</sub>-Adrenergic Receptors and the Risk of Congestive Heart Failure

Kersten M. Small, Lynne E. Wagoner, Albert M. Levin et al. · New England Journal of Medicine · 2002 · 530 citations

Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice

Howard A. Rockman, Kenneth R. Chien, Dong-Ju Choi et al. · Proceedings of the National Academy of Sciences · 1998 · 485 citations · Full text