Concepedia

Comparative Efficacies of TAK-187, a Long-Lasting Ergosterol Biosynthesis Inhibitor, and Benznidazole in Preventing Cardiac Damage in a Murine Model of Chagas' Disease

Rubén Marino Cardozo, María Asunción Segura, Julio A. Urbina, Miguel Á. Basombrío

Antimicrobial Agents and Chemotherapy · 2005 · 44 citations · 9 references

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Abstract

We carried out a comparative study of benznidazole and TAK-187, a long-lasting ergosterol biosynthesis inhibitor, with a murine model of Chagas' disease. The results indicated that TAK-187 was more effective than benznidazole in preventing Trypanosoma cruzi-induced cardiac damage in experimental animals.

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