The Na+/I− Symporter Mediates Iodide Uptake in Breast Cancer Metastases and Can Be Selectively Down-Regulated in the Thyroid

Abstract

This is the first article of in vivo, scintigraphically detected, NIS-mediated I(-) accumulation in human BCM. T(3)/MMI down-regulation of thyroid NIS makes (131)I-radioablation of BCM possible with negligible thyroid uptake and radiation damage.