A convenient synthesis of 2-trifluoromethylpyrroles via base-promoted cyclocondensation of trifluoromethyloxazolones with electron-deficient alkenes

Abstract

The cyclocondensation of trifluoromethyloxazolones with electron-deficient alkenes in the presence of base gives 2-trifluoromethylpyrroles and related heterocyclic compounds in good yields; the reaction involves the tandem Michael addition of trifluoromethyloxazotes to electron-deficient alkenes, intramolecular cyclization and decarboxylation.