Prevention of Ventricular Arrhythmias With Sarcoplasmic Reticulum Ca ²⁺ ATPase Pump Overexpression in a Porcine Model of Ischemia Reperfusion

Abstract

We show that Ca2+ cycling modulation using SERCA2a overexpression reduces ventricular arrhythmias after ischemia-reperfusion. Strategies that modulate postischemic Ca2+ overload may have clinical promise for the treatment of ventricular arrhythmias.