Current Neuropharmacology · 2010 · 240 citations · 61 references
MedicineAnesthesiologyPharmacologyAnesthesiaGeneral AnesthesiaNeuropharmacologyAnesthetic PharmacologyGabaergic NeurochemistryGabaergic PharmacologyGabaergic SignalingGeneral Anesthetic AgentsReceptor PharmacologyGaba AgonistsGaba Receptor SignalingGaba Receptor Subunit PharmacologyGaba-a Receptor PharmacologyGabaergic Neurotransmission ModulationGabaergic Signaling PathwaysGeneral Anesthetic PharmacologyReceptors
General anesthetic drugs interact with many receptors in the nervous system, but only a handful of these interactions are critical for producing anesthesia. Over the last 20 years, neuropharmacologists have revealed that one of the most important target sites for general anesthetics is the GABA(A) receptor. In this review we will discuss what is known about anesthetic - GABA(A) receptor interactions.
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