Contact dermatitis from pheniramine maleate in eyedrops

Abstract

DiscussionFlavoxate hydrochloride, a flavoxate derivative, is used for the treatment of urinary frequency and urinary retension due to neurogenic bladder, chronic prostatitis and chronic cystitis in Japan, UK, USA and Italy.Flavoxate hydrochloride causes certain other adverse effects, e.g., gastrointestinal symptoms and sleepiness (Nippon shin-yaku, personal communication), but no case of drug eruption due to flavoxate hydrochloride has been reported in the English literature.Flavoxate suppresses the overactive bladder by its relaxant activity on the detrusor muscle, and its central suppressive effect on the micturition reflex (1).No case of drug eruption due to the similar well-known drugs,