Total Synthesis of (+)‐β‐Erythroidine

Abstract

Enyne enyne oh! The first total synthesis of (+)-β-erythroidine, a non-aromatic Erythrina alkaloid, is demonstrated. The key steps involved are Lewis acid promoted cyclization of an epoxy–trichloroacetimidate intermediate and tandem ring-closing metathesis (RCM) of the dienyne (see scheme).