The effect of transplanted tumors on the hemolytic behavior of red blood cells from C3H and C57BL mice.

Abstract

Summary 1.Erythrocytes from C3H mice bearing subcutaneous transplants of brain tumors produced with methylcholanthrene showed limited hemolysis. This is in contrast to the marked hemolysis of erythrocytes from nontumor-bearing C3H mice. 2.The hemolytic behavior of the red blood cells of C3H mice bearing brain tumor transplants is similar to that of the red blood cells of C3H mice with spontaneous mammary tumors. 3.The hemolytic behavior was influenced by growth rate and stage of development of the tumor: a )Slowly growing tumors had no effect on the hemolytic behavior of the C3H erythrocytes. b )Tumors with a good rate of growth decreased the hemolysis of the C3H erythrocytes in the early and moderately advanced stages. In the far advanced stages of tumor growth, hemolysis was not decreased. 4.The red blood cells from C57BL mice with transplanted brain tumors showed increased hemolysis only in about one-third of the experiments. This would indicate that the effect of the tumor on the hemolytic behavior of red blood cells of C57BL mice is not so definite as with C3H mice. 5.Suspensions of transplanted brain tumors rarely exerted a hemolytic effect on mouse red blood cells. 6.The importance of the change in hemolysis of erythrocytes during tumor development is discussed.