Concepedia

Are branched chain fatty acids the natural substrates for P450BM3?

Max J. Cryle, Rocio D. Espinoza, Sarah J. Smith, Nicholas J. Matovic, James J. De Voss

Chemical Communications · 2006 · 45 citations · 18 references

DOI

Concepts

Abstract

Branched chain fatty acids are substrates for cytochrome P450(BM3) (CYP102) from Bacillus megaterium; oxidation of C15 and C17 iso and anteiso fatty acids by P450(BM3) leads to the formation of hydroxylated products that possess high levels of regiochemical and stereochemical purity.

References

18

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Linda O. Narhi, Armand J. Fulco · Journal of Biological Chemistry · 1986 · 628 citations · Full text

, , +16

ω-1, ω-2 and ω-3 Hydroxylation of long-chain fatty acids, amides and alcohols by a soluble enzyme system from Bacillus megatyerium

Yoshiro Miura, Armand J. Fulco · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · 1975 · 234 citations

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Fatty acids of the genus Bacillus: an example of branched-chain preference.

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Fatty acid monooxygenation by cytochrome P-450BM-3.

S. Boddupalli, R.W. Estabrook, J.A. Peterson · Journal of Biological Chemistry · 1990 · 202 citations · Full text

, , +16

The Highly Stereoselective Oxidation of Polyunsaturated Fatty Acids by Cytochrome P450BM-3

Jorge H. Capdevila, Shozou Wei, Christian Helvig et al. · Journal of Biological Chemistry · 1996 · 180 citations · Full text

, , +15