Synthesis, characterization, and antibacterial activity of organotin(IV) complexes with 2-hydroxyacetophenone thiocarbohydrazone

Abstract

Abstract Six new organotin(IV) complexes were synthesized by direct reaction of RSnCl3 (R = Me, Bu and Ph) or R2SnCl2 (R = Me, Bu and Ph) and 2-hydroxyacetophenone thiocarbohydrazone [H2APTC] under purified nitrogen in the presence of base in 1 : 2 : 1 molar ratio (metal: base: ligand). Complexes 2–7 have been characterized by elemental analyses, molar conductivity, UV-Visible, IR and 1H NMR spectral studies. Complexes 2–7 are non-electrolytes. The molecular structure of [Me2Sn(APTC)] · (C2H5OH) (5) has been determined by X-ray diffraction analysis. The thiocarbohydrazone ligand (1) and 2–7 have been tested for antibacterial activity against Escherichia coli, Staphylococcus aureus, Salmonella typhi and Enterococci aeruginosa. Keywords: Organotin(IV) complexesThiocarbohydrazone ligandSpectral analysesCrystal structureAntibacterial activity Acknowledgments The authors would like to thank Ministry of Science, Technology and Innovation (MOSTI) and Universiti Malaysia Sarawak (UNIMAS) for the financial support (Grant No. 06-01-09-SF0046). The authors would also like to thank Prof Ismail Ahmad from the Department of Molecular Biology UNIMAS for the antibacterial test.