Temporal Control of Gene Deletion in Sensory Ganglia Using a Tamoxifen-Inducible<i>Advillin-CreERT2</i>Recombinase Mouse

Abstract

Our results suggest that the inducible pan-DRG AvCreERT2 deleter mouse strain is a useful tool for studying the role of individual genes in adult sensory neuron function. The pain phenotype of the Cre-induced animal is normal; therefore any alterations in pain processing can be unambiguously attributed to loss of the targeted gene.