Monoclonal Antibody to Fungal Glucosylceramide Protects Mice against Lethal<i>Cryptococcus neoformans</i>Infection

Abstract

Glucosylceramides (GlcCer) are involved in the regulation of Cryptococcus neoformans virulence. In the present study, we demonstrate that passive immunization with a monoclonal antibody to GlcCer significantly reduces host inflammation and prolongs the survival of mice lethally infected with C. neoformans, revealing a potential therapeutic strategy to control cryptococcosis.