Association between the GH receptor/exon 3 genotype and the level of exon 3-positive GH-binding protein in human serum

Abstract

Our results show that the GHR exon 3 genotype is in accord with the type of GHBP isoforms found in the serum. Our data thus support the idea that the presence of exon 3-retaining and -excluding GHR/GHBP isoforms results from a genomic deletion rather than from alternative splicing.