Concepedia

Advanced Glycation End Products Activate the mi<scp>RNA</scp>/RhoA/<scp>ROCK</scp>2 Pathway in Endothelial Cells

Xiao‐dan Wu, Wei‐lin Liu, Kai Zeng, Hong‐yi Lei, Q Zhang, Shuqin Zhou, Shi‐yuan Xu

Microcirculation · 2013 · 28 citations · 30 references

DOI

Abstract

miR-200b and miR-200c are suppressed in AGE-induced endothelial cell injury, resulting in unregulated RhoA/ROCK2 signaling. Further studies are necessary to evaluate the therapeutic value of targeting miRNAs or their target genes for treatment of vascular diseases.

References

30

MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1

Tamia Harris-Tryon, Munekazu Yamakuchi, Marcella Ferlito et al. · Proceedings of the National Academy of Sciences · 2008 · 1K citations · Full text

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MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation

Nadia Felli, Laura Fontana, Elvira Pelosi et al. · Proceedings of the National Academy of Sciences · 2005 · 762 citations · Full text

Rho and Rac but not Cdc42 regulate endothelial cell permeability

Beata Wójciak‐Stothard, Sandra Potempa, Thomas Eichholtz et al. · Journal of Cell Science · 2001 · 463 citations

miR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition

Alessandra Magenta, Chiara Cencioni, Pasquale Fasanaro et al. · Cell Death and Differentiation · 2011 · 447 citations · Full text

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The Receptor for Advanced Glycation End Products Is Induced by the Glycation Products Themselves and Tumor Necrosis Factor-α through Nuclear Factor-κB, and by 17β-Estradiol through Sp-1 in Human Vascular Endothelial Cells

Nobushige Tanaka, Hideto Yonekura, Sho‐ichi Yamagishi et al. · Journal of Biological Chemistry · 2000 · 423 citations · Full text