<b> <i>Skp2</i> </b> Gene Copy Number Aberrations Are Common in Non-Small Cell Lung Carcinoma, and Its Overexpression in Tumors with <b> <i>ras</i> </b> Mutation Is a Poor Prognostic Marker

Abstract

There appears to be a synergistic interaction between high Skp2 protein expression and ras mutation with negative impact on the survival of NSCLC patients.