Publication | Closed Access
Analgesic and central depressor effects of the dichloromethanol extract fromSchinus molle L.
39
Citations
0
References
1997
Year
Central Depressor EffectsPain MedicineExperimental PharmacologyPharmacological StudyMotor ActivityToxicologyPain ManagementAnesthetic PharmacologyHealth SciencesNeuropharmacologyFurther FractionationPharmacologyPain ResearchSchinus Molle L.PhysiologyAnesthesiaMedicineAnesthesiologyDrug Analysis
The analgesic and central depressor effects of the dichloromethanol extract of Schinus molle L. were analysed in in vivo models. This extract showed low acute toxicity, CNS depressor activity and analgesic effect. Following further fractionation, the hexane/dichloromethane (75/25) fraction showed the most interesting results. Thus, this fraction caused a total inhibition of motor activity and significantly reduced the threshold of pain to chemical stimulus. © 1997 John Wiley & Sons, Ltd.