Population-Specific Risk of Type 2 Diabetes Conferred by <i>HNF4A</i> P2 Promoter Variants

Abstract

These data indicate that the risk conferred by HNF4A P2 is significantly different between U.K. and Ashkenazi populations (P < 0.00007), suggesting that the underlying causal variant remains unidentified. Interactions with other genetic or environmental factors may also contribute to this difference in risk between populations.