Imaging Proteins in Membranes of Living Cells by High‐Resolution Scanning Ion Conductance Microscopy

Abstract

Do not touch! The surface of a living cell is soft and responsive and therefore high-resolution imaging of the cell membrane has not been possible to date. Now noncontact imaging of protein complexes in the plasma membrane of living cells has been demonstrated (see picture) and has been used to follow the cells' structural reorganization. This breakthrough opens up a wealth of new experiments in membrane and cell biology. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z503915_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.