Colistin‐Tobramycin Combinations Are Superior to Monotherapy Concerning the Killing of Biofilm<i>Pseudomonas aeruginosa</i>

Abstract

Colistin-tobramycin combinations are more efficient than respective single antibiotics for killing P. aeruginosa in biofilms in vitro, and they significantly reduced P. aeruginosa cell counts in a rat lung infection model and in patients with cystic fibrosis.