Correlations between holo-transcobalamin II, holo-haptocorrin, and total B12 in serum samples from healthy subjects and patients.

Abstract

The total serum B12 concentration is a relatively poor indicator of holo-TCII concentrations and, therefore, of the ability of serum to deliver B12 to tissues. Additional information regarding B12 values can therefore be gleaned from measuring holo-TCII concentrations in the serum. Low holo-TCII concentrations, however, are an early sign of negative B12 balance and are frequently unassociated with haematological abnormalities caused by B12 deficiency.