Concepedia

A novel myokine, secreted protein acidic and rich in cysteine (SPARC), suppresses colon tumorigenesis via regular exercise

Wataru Aoi, Yuji Naito, Tomohisa Takagi, Yuko Tanimura, Yoshikazu Takanami, Yukari Kawai, Kunihiro Sakuma, Liu Po Hang, Katsura Mizushima, Yasuko Hirai,

Gut · 2012 · 324 citations · 36 references

DOI

Abstract

These findings suggest that exercise stimulates SPARC secretion from muscle tissues and that SPARC inhibits colon tumorigenesis by increasing apoptosis.

References

36

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Pontus Boström, Jun Wu, Mark P. Jedrychowski et al. · Nature · 2012 · 4.6K citations · Full text

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

V. B. Matthews, M.-B. Åström, Stanley M. H. Chan et al. · Diabetologia · 2009 · 698 citations · Full text

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Interleukin-6 Is a Novel Factor Mediating Glucose Homeostasis During Skeletal Muscle Contraction

Mark A. Febbraio, Natalie Hiscock, Massimo Sacchetti et al. · Diabetes · 2004 · 436 citations · Full text

Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise

Douglas J. Mahoney, Gianni Parise, Simon Melov et al. · The FASEB Journal · 2005 · 426 citations

Long-term Exercise and Atherogenic Activity of Blood Mononuclear Cells in Persons at Risk of Developing Ischemic Heart Disease

John Kelly Smith · JAMA · 1999 · 424 citations